HISTORY Essay Example | Topics and Well Written Essays - 1000 words

HISTORY - Essay Example Alexander thus was a far better war tactician than Caesar. However when comparing merits as a ruler, it is not just war exploits and successes that need to be considered, but the issue of what was done for their people, and were the people better off under their rule and subsequent to their rule. At the age of twenty Alexander succeeded his father King Phillip as King of Macedonia. He spent the next few years consolidating his power among the Greek nations, and by 334 BC was ready to set out to conquer the world, though handicapped with a small army, no navy, and lacking in the means to finance his dreams. Still he crossed over into Asia Minor to begin the conquest of the Persian Empire. He conquered Asia Minor and at Syria met the forces of the Persian King Darius and defeated them. Darius fled to Mesopotamia. Alexander took Palestine an Egypt and then turned his eyes on Mesopotamia. He soon conquered Mesopotamia. The vast lands and wealth of the great Persian Empire was all his now. He then turned his attention to Afghanistan and India. He gained Afghanistan and a hold on the north-western parts of India, At this point he had to turn back, as his army had become restless with so many years of fighting away from home. His eastward thrust thus ended in 327 BC, just seven years after he had set out. There is no doubt that no ruler ever has achieved so much in conquests in so limited a period of time (Alexander the Great). The driving force behind Alexander’s dreams of conquering the world is a much debated topic. The debate remains on whether wanting to spread Greek civilization or whether it was his megalomania that was the cause. However there is agreement in that his conquests and the speed at which they were executed remain with a parallel in history. However, the same speed with which the conquests were seen in the collapse of his empire after his death. In that sense his conquests did

IT Managing Business Knowledge and Decision Making Coursework

IT Managing Business Knowledge and Decision Making - Coursework Example This blend assists the communication, operations and advancements in an organization and links its business activities. This is done through an extensive usage of the computer software, data constructs, computer hardware, programming languages, databases and other related components. These components enable a widespread distribution of the messages on a mass level across all the communication channels. Many modern organizations rely on a vast utilization of the information technology in order to render it business operations and services. One of such big organizations is Tesco Plc which forms and leads a huge network of the retail stores operating in various parts of the world. This in organization has been operating in the United Kingdom and other parts of the world since 1919 and has been ranked as the world’s third largest retailer. Other retailers such as Wal Mart follow Tesco in their rankings and services and operations. This Britain-based company having more than 500,00 0 employees and over 4,000 stores manage its huge base of employees and operation in effectives and decentralized structure (Clemens, 2001). The usage of IT plays an important role in the extensive operations, management and governance of Tesco Plc. Many advanced systems and technological equipments have been installed at the company for the purpose of the management of its functions. Some of the examples of such systems include the usage of sophisticated software such as Finance and HR software; supply chain management systems, order processing and scheduling systems and types of communication technology. Besides this, the company utilizes the advanced loyalty cards and car insurance policy quoting systems. The Tesco’s own Tesco Personal Finance system (TPF) allows it to schedule its workforce, and perform food labeling and loan application handling systems. Every checkout in the Tesco’s store manages its Electronic Point of Sale (EPOS) systems and uses computer syste m in the operation and handling of Tesco’s services (Verner, 2000). This usage of IT has a huge impact on the profitability, operations and revenue generation of the company. One of the major ways in which the IT implementation impacts Tesco Plc is increase in the productivity gains and reduction in its costs of production. The customers shopping from Tesco retail stores do not have to go out and but the products. Instead they can sit at home and purchase online through web. Since, the market has become easily accessible to the customers, the productivity gains have increased in the form of customer retention, sales, revenues and other related factors. Besides this, a wide range of purchases are made without any hassle. Moreover, the company can cut their costs of advertisement, EPOS has reduced the employment of the members of staff, and only a few people need to be trained for few short computer and software trainings in the organization. Moreover, the efficiency and effect iveness of the organization is enhanced due to the less wastage and least duplication of the material and human resources of the organization (Clemens, 2001). Besides all the beneficial factors, the features and components of the information technology, such as computer, internet and other databases assist the company to manage its operations and functions. There is a better and

CAR-T Cells in the Treatment of Chronic Lymphocytic Leukemia

CAR-T Cells in the Treatment of Chronic Lymphocytic Leukemia Abstract Cancer has always been a difficult problem to be solved by humans, of which leukemia is one of them. With the development of gene recombination technology and our in-depth understanding of cancer, chimeric antigen receptor T cells (CAR-T) can be carried out in clinical trials. Recently, CAR-T has made new progress in the treatment of acute and chronic lymphocytic leukemia. CAR-T cells are T-cell receptor gene and anti-CD19 antibody gene binding, transfection to T cells, in vitro amplification after transfer to patients for the treatment of leukemia new immunotherapy. The surface of the modified CAR-T cells has a specific binding site, which can recognize the CD19 antigen on the surface of B cells in lymphoblastic leukemia. CD19 antigen can stimulate the continuous activation and proliferation of CAR-T, CAR-T in the patients body can be multiplied hundreds of times, effectively killing acute and chronic lymphocytic leukemia cells. Keywords: car-t cell therapy, chronic lymphocytic leukemia 1. CAR-T principle With the development of gene recombination technology, the specific antibody can be stably expressed on the surface of T cells, so that it has a specific antigen epitope. Chimeric antigen receptor T cell immunotherapy is carried out on the basis of a cellular immunotherapy. The chimeric anti-gen receptor (CARs) is an antigen-recognition domain composed of a specific antibody in the extracellular domain and an antigen-chimeric protein composed of the intracellular CDC3-ÃŽ ¶ chain or FcÃŽ ³I protein linked to the transmembrane domain[1]. After the CARs are recognized and stimulated by specific antigens, they can provide activation signals for T cells and conduct the signals through the intracellular domain, which results in the activation of cells, which are CARs dependent cell activation and cytotoxicity, and cytokines Release [2]. In order to increase the cytotoxicity of CARs, the proliferation of signal transduction was achieved by constructing co-stimulatory molecules connected to the extracellular CD3CÃŽ ¶ in the intracellular domain, resulting in a multiplication of the cell killing effect, which greatly enhanced the CARs Cell killing effect [3]. Generation of CARs intracellular contains only one activation domain, so its specificity in the identification of tumor cell-associated antigens after killing effect is very limited [4]. Second-generation CARs contain an activation domain and a co-stimulatory domain, such as CD28 or 4-1BB [5-6]. The three-generation CARs are composed of the activation domain and multiple co-stimulatory domains, such as CD27, CD28, 4-1BB and OX40. The increase of these domains not only increases the ability of CAR-T cells to specifically recognize TAA and binding , More able to significantly extend the extracellular area of à ¢Ã¢â€š ¬Ã¢â‚¬ ¹Ãƒ ¢Ã¢â€š ¬Ã¢â‚¬ ¹the cell signal transmission, causing lower levels of cell killing cascade [7]. With the improvement of structural design of CARs and the improvement of tumor targeting and kil ling, the researchers have constructed many other intracellular co-stimulatory molecular structures, including CD134, Lck, ICOS and DAP10 [8]. In addition, CD19-derived CAR-T cells were further engineered by researchers at the Duke University Center for Immunology to autocrine IL-12, which may or may not be required in specific syngeneic tumor models Pretreatment chemotherapy, if further extended to clinical patients can be in the lower side effects to obtain better efficacy [9]. Therefore, the continuous innovation of CARs related technologies is not only the structural optimization, but also the construction of more costimulatory molecules in function. The efficiency and function of CAR-T cells will be further improved. 2. Obtain specific CAR-T cells CD19 is a potential target for B-cell neoplasms and can be expressed in normal B cells, follicular dendritic cells, malignant B cells, and precursor B cells in addition to hematopoietic stem cells [10]. Acute and chronic lymphocytic leukemia is usually accompanied by CD19 expression, but in other lymphoid system tumor expression is not the same. Jena and others through genetic modification technology for the first time applied to chronic viral vector, the CD19 + specific chimeric antigen receptorand expression of B cells, transfected into the patients T cells, the transformation of T cells called CD19-specific CAR -T cells [11]. These T cells in vitro after a large number of amplification, re-enter the acute and chronic lymphocytic leukemia patients play a role in the body. CD19-specific CAR-T cells are able to recognize leukemia specific CD19 targets and release B-cells from CD19 cells by releasing a variety of cytokines, thereby promoting the clearance of malignant tumor cells. The results show that, after retroviral gene transfection of T cells, in clinical applications is safe and effective [12]. CD19-specific CAR-T cells have been shown to be effective in attacking CD19 + tumor cell lines and in vivo B-cell tumors in animals [13]. In immunodeficient mice, CD19 + T cells can be effectively removed by the addition of CD19 + T cells [14]. 3. CAR-T cells in the treatment of chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is a slow-growing, inert B-cell leukemia, usually occurring in adults, and many patients can have no symptoms for several years, compared with other types of leukemia. Currently CLL has no specific treatment options, no obvious symptoms of CLL advocates observation and wait, mainly symptomatic treatment, drug therapy is difficult to achieve long-term remission and clinical cure. Genetically modified CAR-T cells have a significant therapeutic effect on B-cell malignancies. The New England Journal reported in June that the June Task Force [15] successfully treated 3 patients with CLL with CAR-T cells for the first time, 2 of whom were still in complete remission after 2 years of follow-up. They subsequently found that [16], the infusion of CAR-T cells in patients with peripheral blood and bone marrow in a large number of survival, proliferation in the body more than 1000 times, effective removal of CLL cells function can be maintained for more than 6 months. Not only that, some CAR-T cells are even in the form of memory cells that produce a rapid response when re-exposed to CLL cells. The mechanisms by which CAR-T cells proliferate and survive in vivo are unclear, probably due to the activation or release of cytokines by normal B cells and CD19-expressing leukemic cells in the internal environment. The cytokines such as IFN-r, CXCL9, IL-6 and soluble IL-2 receptor increased significantly after CAR-T cells entered the body, reaching a peak on the 23rd day after transfusion. Elevated cytokines in bone marrow were consistent with reduced levels of leukemic cells, but TNF levels in peripheral blood and bone marrow did not vary significantly. The number of CAR-T cells in vivo was detected by RT-PCR, and the ratio of cells increased 1000-fold on the 21st day after transfection, accounting for more than 20% of the peripheral blood lymphocytes. The number of CAR-T cells was consistent with the time of oncolytic syndrome and elevated lev els of cytokines. The doubling time of CAR-T cells in peripheral blood was about 1.2 days and the half-life was 31 days. It is noteworthy that cytotoxic side effects such as cytokine release syndrome and macrophage activation syndrome may occur after treatment with CAR-T cell immunotherapy. These symptoms and children hemophagocytic syndrome, lymphoproliferative disease occurs in similar cytokine storm [17]. Cytokine storm is due to CAR-T cells kill B cells caused by tumor cell lysis, characterized by inflammation, long-term fever, hepatosplenomegaly, cell reduction. At this point the laboratory examination of patients with ferritin, triglyceride, transaminase, bilirubin, soluble IL-2 receptor a chain were increased and fibrinogen reduction [18]. CAR-T cells after the input, the patients peripheral blood and bone marrow loss of B cells and hypogammaglobulinaemia up to 6 months or more, but patients do not necessarily have recurrent infection. If the clinical symptoms require symptom atic treatment, the number of CAR-T cells in the patients body or the anti-tumor effect will not be significantly affected. In the past, patients treated with rituximab, after a few months of treatment, B cells can gradually pick up. Whether this phenomenon will occur in patients with CAR-T cell immunotherapy is still unclear. Because CAR-T cells can proliferate extensively and produce cytotoxicity in vivo, CAR-T cell-specific detection is needed in the course of clinical treatment [19], and timely prevention of adverse reactions occurs. 4. Adverse reactions and treatment Although CAR-T cell therapy has achieved surprising clinical results, but have to admit that there are still many cell treatment process risk, adverse reactions after treatment for the treatment of a great test. Because CAR-T can proliferate in vivo and produce severe cytotoxic effects on target cells, the most common and serious is cytokine release syndrome (CRS) [20]. In the current report of CAR-T cells in the treatment of blood cancer cases, almost all appeared in different severity of the CRS response. CRS is mainly due to the large number of cells after activation, including circulating IL-6, ferritin, INFÃŽ ³, IL-2, granulocyte colony stimulating factor IL-10, IL-8, IL-5, including rapid increase in cytokines Caused by fever without cause of infection, persistent hypotension, and even reports of neurological toxicity such as seizures [21-22]. CRS was observed in 48 of the 51 patients treated with CD19-modified CAR-T cells (94%) and serum ferritin levels were greater than 1000 mg / dl in all patients with severe CRS 4-5 C The relationship between the increase of CRP and the course of disease was similar to that of ferritin, but serum C reactive protein and ferritin level did not have significant effect on the prediction of CRS progression. Further, they used 10 healthy volunteers as baseline and found that severe CRS responses within 1 month after CAR-T cell therapy were associated with 24 cytokines including IFNÃŽ ³, IL-6, SGP-130, and SIL6R Serum levels of the peak correlation [23]. Patients with severe CRS response to the survival of patients posed a huge risk, patients with severe hypotension or shock, respiratory distress syndrome, neurotoxicity, liver and kidney dysfunction, it must actively deal with the situation. In addition to the use of vasoactive drugs, tracheotomy and enhanced supportive therapy, the application of IL-6 receptor inhibitor tincture of monoclonal antibody is necessary by inhibiting IL-6 binding to cells and soluble IL-6 And bl ock its classic and bypass IL-6 signal pathway, so after receiving the monoclonal antibody treatment, many patients quickly achieved a good clinical response [24]. CRS can be divided into 5 levels, different levels of recommended CRS treatment is different, it is generally recommended priority early adequate use of trastuzumab to prevent severe CRS response, but because IL-6 mAb is not easy through the blood-brain barrier, 3 to 4 neurotoxic patients, may be preferred to use glucocorticoids to prevent severe CRS. Therefore, IL-6 monoclonal antibody can be relatively early application, can be controlled for CRS and does not affect the efficacy of CAR-T 5. Summary and outlook Nowadays, the clinical application of CAR-T cell therapy, especially the treatment of CD19 CAR-T in hematologic tumors, has made great achievements and the application potential of adoptive immunotherapy as the main representative of CAR-T cell immunotherapy Is very broad. Not only in the blood disease, but also in solid tumors and many benign or chronic diseases, it also has a lot of potential applications. With the development of gene recombination technology and antigen protein construction technology, more CAR-T has been applied to precise targeted therapy. In addition, epitopes expressed on the surface of different blood tumor cells, such as: CD20, CD22, CD34, etc. may also be used as future treatment of other refractory blood diseases targeted to disease treatment to bring a new direction. One of the patients treated with CD19-modified CAR-T cells for MLL rearrangement of B-cell acute lymphoblastic leukemia showed that two patients developed AML after one month of treatment, wh ich may be related to the CD19-negative cellular immune escape Of a mechanism-related [25]. Therefore, the application of CAR-T in combination with multiple epitopes and the sustained killing effect of CAR-T cells in vivo may bring new hope to these cases. There have also been advances in the use of checkpoint inhibitors in combination with CAR-T in the treatment of animals such as AML [26]. However, CAR-T therapy is still a significant clinical risk of adverse treatment, therefore, CAR-T therapy to avoid the safety and toxicity is also a clinical problem to be solved. At present, CAR-T cell therapy for specific antigenic epitopes is combined with nonspecific traditional therapy for tumor cells. It is also a safe and reasonable regimen for the treatment of these diseases, not only killing the tumor cells completely, reducing immune escape and ineffective CAR-T cell immunotherapy, in turn, reduces the dose of non-targeted therapies such as prior chemotherapy and the consequent toxic reactions. Therefore, in the process of discovering new target antigens and constructing precise immunotherapy, The combination of non-targeted drugs and hematopoietic stem cell transplantation is also the research direction of CAR-T cell therapy for a long time. Thus, CAR-T cell therapy has provided new hope for refractory hematologic malignancies, and although there is a pleasing therapeutic effect, more research and further clinical trials are needed, Multi-angle, combined with previous and recent targeted therapy experience, will give CAR-T cell therapy to bring a broader application prospect and exciting clinical efficacy. References: [1] Deniger DC, Switzer K, Mi T, et al.Bispecific T-cells expressing polyclonal repertoire of endogenous gammadelta T-cell receptors and introduced CD19-specific anti receptor[J].Molecular therapy:the journal of the AMerican society of gene therapy, 2013, 21(3):638-647. [2] Jena B, Dotti G, Cooper LJ.Redirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor[J].Blood, 2010, 116(7):1035-1044. [3] Wang J, Jensen M, Lin Y, et al.Optimizing adoptive polyclonal T cell immunotherapy of lymphomas, using a chimeric T cell receptor possessing CD28 and CD137 costimulatory domains[J].Human gene therapy, 2007, 18(8):712-725. [4] Jensen MC, Popplewell L, Cooper LJ, et al.Antitransgene rejection reponses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans[J].Biology of blood and marrow transplantation:journal of the American society for blood and Marrow transplantation, 2010, 16(9)à ¯Ã‚ ¼Ã… ¡1245-1256. [5] Kowolik CK, Topp MS, Gonzalez S, et al.CD28 Costimulation provided through a CD19-specific chimeric antigen receptor enhances in vivo persistence and antitumor efficacy of aoptively tyansferred T cell[J].Cancer research, 2006, 66à ¯Ã‚ ¼Ã‹â€ 22à ¯Ã‚ ¼Ã¢â‚¬ °Ãƒ ¯Ã‚ ¼Ã… ¡10995-11004. [6] Sanchez-paulete AR, Labiano S, Rodriguez-ruiz ME, et al.Deciphering CD137(4-1BB) signaling in T cell costimulation for translation into successful cancer immunotherapy[J].European journal of immunology, 2016, 46(3):513-522. [7] Pule MA, Straathof KC, Dotti G, et al.A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of Primary human T cell[J].Molecular therapy:the journal of the American society of gene therapy, 2005, 12(5):933-941. [8] Zhao Y, Wang QJ, Yang S, et al.A herceptin-based chimeric antigen rcetor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity[J].Journal of immunology, 2009, 183(9):5563-5574. [9] Pegram HJ, Lee JC, Hayman EG, et al.Tumor-targeted T cells modified to secrete IL-12 cradicate systemic tumors without need for prior conditioning[J].Blood, 2012, 119(18):4133-4141. [10] Morgan RA, Yang JC, Kitano M, et al. Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing Eà ¯Ã‚ ¼Ã‚ ²BB2. Mol Ther, 2010; 18 ( 4) : 843-851à ¯Ã‚ ¼Ã… ½ [11] Jena B, Dotti G, Cooper L. à ¯Ã‚ ¼Ã‚ ²edirecting T-cell specificity by introducing a tumor-specific chimeric antigen receptor. Blood, 2010; 116 ( 7) : 1035-1044à ¯Ã‚ ¼Ã… ½ [12] Scholler J, Brady TL, Binder-scholl G, et al. Decade-long safety and function of retroviral-modified chimeric antigen receptor T cellsà ¯Ã‚ ¼Ã… ½ Sci Transl Medà ¯Ã‚ ¼Ã…’2012; 4( 132) : 132ra53à ¯Ã‚ ¼Ã… ½ [13] Brentjens RJ, Latouche JB, Santos E, et al.Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15.Nat Med, 2003; 9( 3) : 279-286. [14] Brentjens à ¯Ã‚ ¼Ã‚ ²J, Santos E, Nikhamin Y, et al. Genetically targeted T cells eradicate systemic acute lymphoblastic leukemia xenografts.Clin Cancer à ¯Ã‚ ¼Ã‚ ²es, 2007; 13( 18) : 5426-5435. [15] Porter DL, Levine BL, Kalos M, et al.Chimeric antigen receptormodified T cells in chronic lymphoid leukemia.N Engl J Med, 2011; 365( 8) : 725-33à ¯Ã‚ ¼Ã… ½ [16] Kalos M, Levine BL, Porter, DL, et al. T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.Sci Transl Med, 2011; 3( 95):95 ra73. [18] Janka G.Familial and acquired hemophagocytic lymphohistiocytosis.Annu rev Med, 2012; 63( 1) : 233-246à ¯Ã‚ ¼Ã… ½ [19] Kohn DB, Dotti G, Brentjens R, et al. CARs on track in the clinic.Mol Ther, 2011; 19( 3) : 432-438à ¯Ã‚ ¼Ã… ½ [20] Maude SL , Barrett D, Teachey DT, et al. Managing Cytokine Release Syndrome Associated With Novel T Cell-Engaging Therapies[J].Cancer journal(Sudbury, Mass), 2014, 20(2):119-122. [21] Grupp SA, kalos M, Barrett D, et al. Chimeric antigen receptor-modified T cells for acute lymphoid leukemia[J].The New England journal of medicine, 2013, 368(16):1509-1518. [22] Kochenderfer JN, Dudley ME, Feldman SA, et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells[J]Blood, 2012, 119(12):2709-2720. [23] Lee DW, Gardner R, Porter DL, et al. Current concepts in the diagnosis and management of cytokine release syndrome[J]Blood, 2014, 124(2):188-195 [24] Teachey DT, Rheingold SR, Maude SL, et al.Cytokine release syndrome after blinatumomab treatment related to abnormal macrophage activation and ameliorated with cytokine-directed therapy[J].Blood, 2013, 12(26):5154-5157 [25] Gardner R, Wu D, Cherian S, et al.Acquisition of a CD19-neg-ative myeloid phenotype allows immune escape of MLL-rear-ranged B-ALL from CD19 CAR-T-cell the rapy[J].Blood, 2016, 127(20):2406-2410. [26] Saad S Kenderian MR, OL ga Shestova, Michael Klichishky, et al.Idntification of PD1 and TIM3As Checkpoints that Limit Chimeric Anti gen Receptor T Cell Efficacy in Leukemia[j]Bood, 2015, 126(23):852-852

Janes Resilience to Events in Jane Eyre Essay -- Jane Eyre Charlotte

Jane's Resilience to Events in Jane Eyre The novel Jane Eyre was written by Charlotte Bronte in the 1840’s. Put simply, it is the story of a woman who began her life with nothing but aspired, against the odds, to gain recognition and a better social status. Moreover, it is about her ability to cope with situations and make decisions that affect her life and others. Through these qualities it is possible to describe her as a heroine. This essay will aim to show how Bronte conveys Jane’s resilience – her ability to cope and repel suffering – to the audience. It will also show how Bronte shows how Jane could be considered a heroine; not in the clichà ©d sense of fighting evil but more like her ability to choose good over evil, her selflessness, her courage and her overbearing will to continue to live. With such a poor social status (she was an orphan and a women, who were seen as inferior and had far less opportunities in life during the 1800s than men did), no money and no friends the character Jane needed more than a little ambition and feistiness to succeed in overcoming her obstacle-ridden life. Bronte presents Jane at the beginning of the story as a young girl. She is an orphan who lives with her aunt - Miss Reed - but is extremely disliked by her because it was her uncle who adopted her and is now dead. She also lives with Miss Reed’s three children, Eliza, Georgiana and John who also despise her. Bronte communicates Jane’s status in the family early on - Jane is considered an outcast and treated as inferior to the rest of the family. The torment she suffers is clear from the very beginning of the story, and Bronte is quick to associate Jane’s relationship with the Reeds with feelings of mis... ...dly how Jane evolves from a quiet and bullied girl to a full-grown woman capable of loving with all her heart, respecting herself and finding happiness in unhappy situations. Bronte also shows how Jane becomes a strong individual. I think the novel shows very well how badly women were treated in the 1800’s but also why they deserved the same respect as men. It also showed that status in society does not affect whether a person is bad – this contrast is shown by Bronte in Jane, an orphan girl, being good, and the Reeds, a rich respected family, being horrible. Overall it is a very encouraging story, with many tragic moments but also a happy ending. It not only leaves the reader understanding how social status was viewed in the 1800’s but also leaves them with a feeling of hope and the idea that anyone can change who they are, if they are good people.

Themes in Tale of Two Cities

?Throughout Charles Dickens Tale of Two cities, a few different themes can be easily spotted. The biggest prevailing theme in the book would have to be the 99% vs the 1% elite. This is when the poor oppressed people have had enough of the wealthy elite controlling them, and they ban together and rise up against it. In desperate times like revolution, you often find two or more unexpected partners, or allies. It is almost as if the revolution and uprising causes some bond between the people revolting, giving them extreme focus and teamwork.In normal circumstances, you might expect a woman like Madame’ Defarge to be a quiet mellow woman, but get her in a revolution and she turns in to a fiery death machine. Themes like these can still be spotted today, and most of the same rules apply. One example in the most is the revolution and rebellion in Syria. This is virtually a near exact modern example of something that Charles Dickens wrote in Tale of Two Cities 100 years ago. This pr oves the themes, and subplots found in his books are just as real today, as they were back then. Syrian people where being horribly mistreated, to the point of thousands dying.You could draw a parallel between Syria’s leader Assad and the Marquis in St. Antoine. Both these leaders oppressed the people, and did nothing to stop widespread poverty and hunger, while still pretending everything in the country is perfect. This makes it clear that evil leaders, and tyrants will always be the same; they are blind to the trouble they cause. Throughout the theme of social oppression, it also brings you to recognize the strong family links and ties within the book. It focuses strongly on the different links within the family, while the opposing family is trying hard to break that link.While we may not see families killing each other nowadays, some relevance to it can still be seen. One example is the strong link between Darnay and Lucie loving each other so dearly, while her dad is utte rly shocked she is married to a man that helped throw him in prison. Things like this are still found today, and it isn’t uncommon to hear about fights between in-laws. People still tend to hold grudges from the past and cause it to affect their opinions and decisions in the future, much like the theme in Tale of Two Cities.So all in all, it can be said there is definite evidence of themes Charles Dickens wrote about, in the modern world. The reason for this is that the mentality of people often doesn’t change much over time. A tyrant leader will always be a tyrant, and angry in-laws will always be angry in-laws. This is simply the human nature, and it likely won’t fade anytime too soon. While we might not go physically cutting people’s heads of, Charles Dickens theme of social injustice is very relevant today. Themes in Tale of Two Cities Throughout Charles Dickens Tale of Two cities, a few different themes can be easily spotted. The biggest prevailing theme in the book would have to be the 99% vs the 1% elite. This is when the poor oppressed people have had enough of the wealthy elite controlling them, and they ban together and rise up against it. In desperate times like revolution, you often find two or more unexpected partners, or allies. It is almost as if the revolution and uprising causes some bond between the people revolting, giving them extreme focus and teamwork.In normal circumstances, you might expect a woman like Madame’ Defarge to be a quiet mellow woman, but get her in a revolution and she turns in to a fiery death machine. Themes like these can still be spotted today, and most of the same rules apply. One example in the most is the revolution and rebellion in Syria. This is virtually a near exact modern example of something that Charles Dickens wrote in Tale of Two Cities 100 years ago. This pro ves the themes, and subplots found in his books are just as real today, as they were back then. Syrian people where being horribly mistreated, to the point of thousands dying.You could draw a parallel between Syria’s leader Assad and the Marquis in St. Antoine. Both these leaders oppressed the people, and did nothing to stop widespread poverty and hunger, while still pretending everything in the country is perfect. This makes it clear that evil leaders, and tyrants will always be the same; they are blind to the trouble they cause. Throughout the theme of social oppression, it also brings you to recognize the strong family links and ties within the book. It focuses strongly on the different links within the family, while the opposing family is trying hard to break that link.While we may not see families killing each other nowadays, some relevance to it can still be seen. One example is the strong link between Darnay and Lucie loving each other so dearly, while her dad is utter ly shocked she is married to a man that helped throw him in prison. Things like this are still found today, and it isn’t uncommon to hear about fights between in-laws. People still tend to hold grudges from the past and cause it to affect their opinions and decisions in the future, much like the theme in Tale of Two Cities.So all in all, it can be said there is definite evidence of themes Charles Dickens wrote about, in the modern world. The reason for this is that the mentality of people often doesn’t change much over time. A tyrant leader will always be a tyrant, and angry in-laws will always be angry in-laws. This is simply the human nature, and it likely won’t fade anytime too soon. While we might not go physically cutting people’s heads of, Charles Dickens theme of social injustice is very relevant today.

Computerized Enrollment System Essay

Computer now a days have a vital and wonderful effect in all aspects of a human being from a single thing or relating to human beings living in society. This advance technology has been the range or scope of something to influence the society’s modernization. We are therefore enhancing the development of our society through the use of computer. It is also made by computer-based system to lessen the work of the employees in organization. One of the computer-based systems is the computerized enrollment system, in which it is essential in the development of the organization that provides the information needed by the organization for achieving results without waste of time and effort and producing a specified effect. Almost every company and institution here in our country uses a computer based system. This type of system makes their work fast, accurate and reliable. This is the best way of storing and retrieving data on a server or a hard disk rather than using papers and file cabinets. A quick and reliable computer based system is a process wherein an institution can find an easier and better way to implement an enrollment system. In the case of Sto. Nià ±o Academy, it is composed of manual enrollment system, wherein all transactions during enrollment period are done manually and using the traditional way. Computation of payments which is done manually through the use of the usual calculators, and even the generation of reports are very time consuming. Background of the Study The major problem of the Sto. Nià ±o Academy is the slow process of admitting a student when enrolling, especially in the middle of the enrollment period. The proponents decided to develop a Computerized Enrollment system to make the process of admitting student fast and accurate. The system that will developed by the proponents is a great help to the school because it provides efficient and accurate transactions, and also, it provided a security to prevent unauthorized person to access the system. In registration and record keeping, the registrar’s work will be lessen and hustle free. The records no will be more secured than the previous way of keeping the records. In cashier, the time for computing, and checking of balances will be lessen and more efficient. The system is providing a search engine for the student that has a balance remaining. For student, the time in enrolling will be lessen and efficient, accurate, and hustle free. The system is pro viding a module for automatic computation of the average grade of the student, room assignment is also included. Objective of the Study General Objective The study aims to improve the traditional procedures of the enrollment of Sto. Nià ±o Academy by designing and developing a Computerized Enrollment System. This will be a great help in improving the existing enrolment system and will mitigate errors in admitting, assessing students, and computation of payments during enrollment and examination period. Through this way, the proposed system will give comfort to both the students and the staff of the school. It will also make every transaction fast and accurate. It will lessen the errors especially in the assessment and computation of payments and generation of reports. Specific 1. To provide a module that will prohibit access to unauthorized user. The proponents will design and develop a module that will prohibit access to unauthorized users. This module will provide usernames and passwords for the identification of the user. To ensure the security of data, the system will provide levels of access on every data. Only authorized persons can modify the data through the use of database security. Through this, confidential files will be secured. 2. To provide a module that will make the assessment and computation of payments fast and accurate. The proponents will design and develop a module that will automatically compute the tuition of a certain enrollee based on the mode of payment. This module will provide an accurate and faster computation of student tuition fees so that the registrar doesn’t have to double-check her computation to save time and effort. 3. To provide a module that will maintain all the student records in the school. At Sto. Nià ±o Academy, the records of the students are only kept in folders or envelopes. With this, the proponents will design and develop a Database Module that will serve as the storage of all the records about the system because all data are stored in it. Through this module, all files will be organized so that they can easily be accessed and retrieved. This module will also provide the maintenance of records of the students. In this way, it will be easy to update and delete record to provide an up-to-date list of students. 4. To provide a module that automatically computes the average grade of a student. This module will help the registrar in admitting a promoted student during enrollment. Now promoted students can skip registration and evaluation of grades, he can already go to the cashier for assessment 5. To provide an Automatic Sectioning module during enrollment. This module will give the section to a student during enrollment period. This will save time and effort for the students. Based on the manual posting of schedule, students are required to go to their rooms to get their schedule. Now with the help of the proposed system, students will immediately get their schedule after they enrolled. 6. To provide a module that will make the generation of reports fast and accurate. Student Report Sto. Nià ±o Academy is required to submit different reports to the Department of Education. These are the reports of all the students currently enrolled in a particular school year. With the manual way, the registrar is having a hard time of finding and transferring the report to a specific report paper. That’s why the proponents will design and develop a module that provides an accurate, fast, reliable, and easy generation of reports. Student Grade The system is also capable of storing student grades. Through the use of the system, it would be easy for the teachers to encode the student’s grades. The teachers have individual usernames and password in order to gain access to the student’s grades. The error for the teacher to post in accurate grades on the student’s records will lessen. Faculty Information Generation of reports of certain faculty information will be made easier with the implementation of the system. The computerized system is capable of generating reports fast, accurate and error less. Preparation of reports using manual method will be eliminated because the registrar does not need to write everything. With just clicking the print button and selecting the faculty that you want to print his information, the system will print all the necessary information needed. 7. To provide a module that will make the searching of student grade fast. Searching of a student record is also a problem of Sto. Nià ±o Academy, because whenever students go to the registrar to get his grades the registrar needs to go to the file cabinet and look for the name of the student that takes a long time and effort. This module is design for fast searching of a certain student, by means of typing his student number or last name. 8. To provide a module that will retrieve student records. Retrieval of records is also a problem of registrar. Every time a certain record is being retrieved, the process takes a lot of time for the registrar needs to search over files records in order to have the records retrieved. But with the use of the computerized system, retrieval of records will be easier because the system only requires the student number as an input and with just a click of a button, the records being searched will be displayed on the screen and is ready for printing, thus making the retrieval of records easier and faster.